Pharmaceutical therapy includes the use of oral drugs, injections in the cavernous bodies, intra-urethral therapy and local remedies.
Depending on the prescription, all the drugs for the treatment of erectile dysfunction are taken orally, transdermally, buccally, subcutaneously or transrectally.
Injections in the cavernous bodies
Injections in the cavernous bodies were first used by scientists in 1982. Thus, Virag and Brindley found the way to restore erection. The first drug licensed for this kind of injections was prostaglandin, used since 1988. The main advantage of this drug is the reduction of side effects and risk of priapism. The fundamental flaw of this drug (risk of priapism), was minimized during the development of the new medicine, based on vasoactive polypeptide and phentolamine (the use of which almost eliminates the risk of priapism). However, most patients refuse from this method, as the injections in the cavernous bodies are quite painful.
Alkaloids, widely popular in the USA, are now commonly used for the treatment of erectile dysfunction. There are two research studies that prove the effectiveness of alkaloids in the treatment of ED of psychological and organic character. However, placebo has also shown positive result in both cases. The modern scientists suggest that yohimbine, contained in alkaloids, significantly reduces the adrenergic stress component and increase the blood flow to the penis due to its а-blocking properties. This indicator is considered the most effective for the treatment of psychological erectile dysfunction (especially if it is caused by stress).